Up down left and right

When I move my LR using repetier host is there a correct way? I assume the Z up should send the low rider up, but what about the other directions. I’m guessing it can be made to work in any direction, but is there one way that its setup to be. If Z positive is up then is it setup to follow the right hand rule?

On the low rider, if you are using the Dual endstop firmware, it is set up as dual Y axis, not dual X. If you are using serial firmware, you can make it how you like. If you want dual endstop with dual X, you have to modify the firmware.

Thank you for that information. I am using the duel end stop firmware so I will set mine up for dual Y to keep it simple.