What? Are you going to fill it with puppies or something?
That’s huge. The z axis can lift quite a lot. It’s very strong. I don’t want to put a number on it, but at least a six pack. But if there is a large weight at the end of a 10’ long z axis, it will bind or even bend or break something. Also, the x and y axes will not be very strong. You can add support to the outside rails, but the middle rails will bend. Just with the gantry they will flex a few inches.
Also, a 10’ z axis is going to be a mess. I don’t know if you can find T8 leadscrews that long. The 5/16" might work, but max speed will still be about 8mm/s. So, 3-4min to raise and lower it. Also, you’ll need 10 more feet above the machine.
Why so big? Especially in height?