So “large” is kind of subjective, or debatable here. Core XY is not good for Giant builds, and for giant build giant extruders should be used. So in a giant build an MPCNC is probably easily the better choice. Large to me would be 300-400mm range and the linear guides / corexy are great for this. Giant is anything over that.
To me, personal choice here, was to make a good production printer. 8 printers is a lot to manage, I do not want to add more, I would rather print faster and maintain less. The V3 (repeat) is faster than the V1&2 but the CF tube did not handle 24/7 use. I blasted all the CF rails now, in a few months. My hope is the linear guides are less maintenance required. Using emt increases maintenance (occasional adjustments and tube turning) and the hardware increases size/footprint.
That is kinda why I don’t really ever support the printers like the CNC’s. The printers are 100% built to what I need and want, where the CNC’s are trying to do it all.
I do not like the Extrusions much either, but for the dimensions I prefer to hold for my printed parts that I sell the extrusions allow for me to very easily fine tune all aspects very quickly. If you look around at any 3D printer company, I do not think once I have ever seen accuracy listed, at best you will get an accuracy possible number. micro-step calculations. I try to adjust the V3 and V4 to under ±0.2mm off 150mm compared diagonals in any axis. If you even look at tuning guides I don’t think I have ever even seen a Zx Zy calibration procedure as most printers have no way to adjust them. Early printers had adjustable diagonal stabilizers, those seen to have disappeared. BUT…I have actually still made V4 to fit in a wood box, with the exception of the right XY stepper, that would need a vertical mount instead for the 90 I just added. Pretty easy fix, if you are not needing such exact dims.